Origin of CBD
In the world where nutraceuticals and phytochemicals are progressing Cannabidiol oil is marking its territory. Cannabidiol originated from Cannabis Sativa or better known as the Marijuana plant, it was used by early people when medicine was not widely available. In 2900 B.C it was used to relieve pain. It is one of 104 compounds called cannabinoids. An interesting fact in the discovery of Cannabidiol is its difference from marijuana. Most people confuse it with marijuana as they both were extracted from the same plant but they differ in only one compound called tetrahydrocannabinol (THC) that makes marijuana the drug that gets a person High. THC is the psychoactive component that alters the conscious state but also provides the stress-free environment, whereas Cannabidiol has more benefits than side effects that is why it is legal in most of the states of America where marijuana is also legal. Still, researches and experiments are being conducted to further explore all the beneficial and harmful effects of this extract.
Uses of CBD in different medical conditions
Many individuals across the globe have been using CBD as part of their treatment. Its benefits are increasing day by day, most importantly it is being used to treat symptoms and a few types of cancer. Internet and blogs are filled with queries of people who are looking into CBD for treating their loved ones. Evidence-based study has shown that CBD is being used against childhood epilepsy and it has responded to conditions like Dravet Syndrome in which anti-seizure medication have not responded to cure it, whereas CBD was able to stop the seizures altogether, making it the first legal cannabis-derived medicine.
One of the most intriguing benefits of marijuana is its role in the treatment of insomnia. As of now, researchers understand that sleep is divided into multiple cycles with different phases, and it is generally regarded that CBD oil increases sleep in the third phase, which is the “deep sleep” phase. Furthermore, it has been shown that CBD decreases the duration of REM sleep, which is a phase of light sleep and is also the phase where dreams occur. By reducing REM sleep, people dreamless (meaning better quality sleep), their memory may be improved, and symptoms of depression may be decreased.
Researches and experiments conducted showed that CBD relieves chronic pain including pain due to arthritis. The European Journal of pain showed cases in which CBD proved useful in treating pain and reducing inflammation in many parts of the body. Some cases have depicted the combined effects of CBD and THC to relieves major pains and treat conditions like multiple sclerosis. The combination proved useful but some in some cases the patients left due to an increase in anxiety. CBD played its part in a simple mechanism the endocannabinoid system that controls most of the functions like controlling appetite, maintaining the immune system, regulating sleep and manage pain, the body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system. Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters.
Depression and anxiety two of the most common words heard either from adolescents or from people who had post-traumatic stress disorder. This stress in youngsters is probably one of the reasons they get addicted to marijuana but CBD actually helped in treating depression by acting with the brain’s receptor, serotonin that helps in a better mood and social behavior.
Online reviews and several studies showed that CBD relieved many symptoms that were induced due to chemotherapy. Nausea and vomiting after chemo were reduced and patients felt relieved by it. Initial research published in the Journal of Alzheimer’s Disease found that CBD was able to prevent the development of social recognition deficit in participants. This means that CBD could help people in the early stages of Alzheimer’s to keep the ability to recognize the faces of people that they know. This is the first evidence that CBD may slow the progression of Alzheimer’s disease.
Another intriguing benefit that CBD possessed was reducing acne, it nullified one reason that was the over-production of sebum by the sebaceous gland. I=due to its anti-inflammatory properties this compound was able to reduce the inflammation around the glands hence less the oil lesser the acne.
Side effects of CBD
In addition to all the above benefits, CBD has also proven effective for heart health by reducing the high blood pressure that can cause many other ailments including stroke. It has also been linked to improving diabetes and reducing it by 56%. Contributing to antipsychotic treatment and reducing many diseases whose cure was not possible with medication.
As with every action, there is a possible reaction, in the same way with every benefit there is a harmful effect. The first and most dangerous side effect of CBD is its effect on the liver. While it reduces inflammation on one hand, on another hand it interacted with liver enzymes and raises its levels. It is known to interact with drug-metabolizing enzymes such as the cytochrome P450 family. Well over half of ALL pharmaceutical drugs are metabolized by the CYP3A4 enzyme which is also responsible for how CBD is metabolized.
There are specific drugs that hinder CYP3A4 which can slow the breakdown of CBD and increase its rate of physiological activity. Then there are other drugs which increase levels of the enzyme and ensure rapid CBD breakdown. It must be said that CBD also has positive effects on liver enzymes. It boosts the rate of CYP1A1 production which can breakdown carcinogenic substances such as benzopyrene.
Contributing to recovery there are almost equal chances that CBD caused nausea and anxiety in many individuals. It action with other drugs have caused numerous side effects including anxiety and diarrhea in some case. It also has been a source of discomfort for many people. It was also evident from the research that 600 mg of CBD oil was proven effective, so if the amount was low the effects were not fruitful. In the case of different disease, a specific amount has been prescribed like
- Loss of Appetite in Cancer Patients: 2.5mg of THC (orally), with or without 1mg of CBD for six weeks.
- Chronic Pain: 2.5-20mg of CBD [with or without THC] (orally).
- Epilepsy: 200-300mg of CBD (orally) daily.
- Movement Problems Due to Huntington’s Disease: 10mg of CBD per kg of body weight daily for six weeks (orally
- Sleep Disorders: 40mg-160mg of CBD (orally).
- Multiple Sclerosis (MS) symptoms: Cannabis plant extracts containing 2.5-120 milligrams of a THC/CBD combination daily for 2-15 weeks. Patients typically use eight sprays within any three hours, with a maximum of 48 sprays in any 24-hour period
- Schizophrenia: 40-1,280mg oral CBD daily.
- Glaucoma: A single sublingual CBD dosage of 20-40mg (>40 mg may increase eye pressure)
Effect of overdose of CBD
The overdose effects have yet not been researched which is the biggest back draw in its use.
In New York, a study that was led by scientist proved that patients with chronic kidney disease had their kidneys function decline faster than in non-cannabis users, which means that their kidneys were not able to filter the waste it is supposed to. Like in the case of protein intake all the end product would start accumulating and may cause health concerns.
CBD oil caused skin issues in many participants it causes dryness and also causes a disturbance in gut function.
Precautions and safety of CBD to Avoid Side Effects
While using CBD some precautions must be taken to ensure safety. Like in the following cases instructions must be followed and must consult with a physician.
- Pregnancy and breastfeeding: There is not enough reliable information about the safety of taking Cannabidiol if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
- Parkinson’s disease: Some early research suggests that taking high doses of Cannabidiol might make muscle movement and tremors worse in people with Parkinson’s disease.
When it comes to concluding that whether the product is safe or not, there are several aspects that should be considered while giving your decision. Enlisting the pros and cons cannabis has both but the point is that if the drug is worth taking a risk for? Lack of research in many areas and insufficient evidence in many cases have revealed that if consumed then it should only be consumed for conditions that are scientifically proven that this will work like Bipolar disorder. Early reports suggest that taking Cannabidiol daily does not improve manic episodes in people with bipolar disorders. A muscle disorder called dystonia. Early research suggests that taking Cannabidiol daily for 6 weeks might improve dystonia by 20% to 50% in some people. But higher quality research is needed to confirm this. Parkinson’s disease. Some early research shows that taking Cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson’s disease and psychosis. But taking a specific cannabis extract that contains THC and Cannabidiol does not appear to improve involuntary muscle movements caused by the anti-Parkinson’s drug levodopa in people with Parkinson’s disease.
- Schizophrenia. Research on the use of Cannabidiol for psychotic symptoms in people with schizophrenia is mixed. Some early research suggests that taking Cannabidiol four times daily for 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. But other early research suggests that taking Cannabidiol for 14 days is not beneficial. The mixed results might be related to the Cannabidiol dose used and the duration of treatment.
Is CBD safe to use?
There is a lot of MIGHT work in this area. One other minus point is its legality that it is not legal in many countries due to THC but it has been proven that CBD is not addictive and it does not alter the person’s mental state. That is a person feel high on clouds after ingesting it.
is POSSIBLY SAFE when taken by mouth and appropriately in
adults. Cannabidiol doses of up to 300 mg daily have been used safely for up to
6 months. Higher doses of 1200-1500 mg daily have been used safely for up to 4
weeks. Cannabidiol sprays used under the tongue have been used in doses of 2.5
mg for up to 2 weeks.
Some reported side effects of Cannabidiol include dry mouth, low blood pressure, lightheadedness, and drowsiness.
Yet when many benefits can be achieved by an extract from a small plant why not use it to save lives and spread ease for people dealing with different and progressing diseases. It’s worth taking a risk when your life is at stake. More researches should be carried to eliminate the loopholes in this area of study.